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Livres
Articles (41)
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In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells

Holmgaard, Andreas, Askou, Anne Louise, Benckendorff, Josephine Natalia Esther, Thomsen, Emil Aagaard, Cai, Yujia, Bek, Toke, Mikkelsen, Jacob Giehm, Corydon, Thomas J.

Journal:

Molecular Therapy — Nucleic Acids

Année:

2017

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2017

Identification of BLNK and BTK as mediators of rituximabâinduced programmed cell death by CRISPR screens in GCBâsubtype diffuse large Bâcell lymphoma

Thomsen, Emil Aagaard, Rovsing, Anne Bruun, Anderson, Mads Valdemar, Due, Hanne, Huang, Jinrong, Luo, Yonglun, DybkÃ¦r, Karen, Mikkelsen, Jacob Giehm

Journal:

Molecular Oncology

Année:

2020

Fichier:

PDF, 22.18 MB

2020

A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues

Nicklas H Staunstrup, Nynne Sharma, Rasmus O Bak, Lars Svensson, Thomas K Petersen, Lene Aarenstrup, Karsten Kristiansen, Lars Bolund, Jacob Giehm Mikkelsen

Journal:

BMC Biotechnology

Année:

2011

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2011

Genetic reassortment and patch repair by recombination in retroviruses

Jacob Giehm Mikkelsen, Finn Skou Pedersen

Journal:

Journal of Biomedical Science

Année:

2000

Langue:

english

Fichier:

PDF, 3.66 MB

english, 2000

Establishment of a pig fibroblast-derived cell line for locus-directed transgene expression in cell cultures and blastocysts

Jannik E. Jakobsen, Juan Li, Brian Moldt, Peter M. Kragh, Henrik Callesen, Jens Michael Hertz, Lars Bolund, Arne Lund Jørgensen, Jacob Giehm Mikkelsen, Anders Lade Nielsen

Journal:

Molecular Biology Reports

Année:

2011

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2011

Lentiviral vectors for cutaneous RNA managing

Maria Nascimento Primo, Rasmus O. Bak, Jacob Giehm Mikkelsen

Journal:

Experimental Dermatology

Année:

2012

Langue:

english

Fichier:

PDF, 416 KB

english, 2012

Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo

Yant, Stephen R., Ehrhardt, Anja, Mikkelsen, Jacob Giehm, Meuse, Leonard, Pham, Thao, Kay, Mark A.

Journal:

Nature Biotechnology

Année:

2002

Langue:

english

Fichier:

PDF, 2.95 MB

english, 2002

Adeno-associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo

Maria Pihlmann, Anne Louise Askou, Lars Aagaard, Gitte Hoffmann Bruun, Jesper Dyrendom Svalgaard, Marie Hebsgaard Holm-Nielsen, Frederik Dagnæs-Hansen, Toke Bek, Jacob Giehm Mikkelsen, Thomas Gryesten

Journal:

The Journal of Gene Medicine

Année:

2012

Langue:

english

Fichier:

PDF, 360 KB

english, 2012

Efficient replication of full-length murine leukemia viruses modified at the dimer initiation site regions

Lars Aagaard, Søren Vestergaard Rasmussen, Jacob Giehm Mikkelsen, Finn Skou Pedersen

Journal:

Virology

Année:

2004

Langue:

english

Fichier:

PDF, 595 KB

english, 2004

Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin

Rasmus O Bak, Karin Stenderup, Cecilia Rosada, Line B Petersen, Brian Moldt, Frederik Dagnæs-Hansen, Maria Jakobsen, Søren Kamp, Thomas G Jensen, Tomas N Dam, Jacob Giehm Mikkelsen

Journal:

BMC Dermatology

Année:

2011

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2011

Modulation of Homo- and Heterodimerization of Harvey Sarcoma Virus RNA by GACG Tetraloops and Point Mutations in Palindromic Sequences

Søren Vestergaard Rasmussen, Jacob Giehm Mikkelsen, Finn Skou Pedersen

Journal:

Journal of Molecular Biology

Année:

2002

Langue:

english

Fichier:

PDF, 2.56 MB

english, 2002

Regulation of pro-inflammatory cytokines TNFα and IL24 by microRNA-203 in primary keratinocytes

Maria Nascimento Primo, Rasmus O. Bak, Beatrice Schibler, Jacob Giehm Mikkelsen

Journal:

Cytokine

Année:

2012

Langue:

english

Fichier:

PDF, 737 KB

english, 2012

Reduction of choroidal neovascularization in mice by adeno-associated virus-delivered anti-vascular endothelial growth factor short hairpin RNA

Askou, Anne Louise, Pournaras, Jean-Antoine C., Pihlmann, Maria, Svalgaard, Jesper D., Arsenijevic, Yvan, Kostic, Corinne, Bek, Toke, Dagnaes-Hansen, Frederik, Mikkelsen, Jacob Giehm, Jensen, Thomas G

Journal:

The Journal of Gene Medicine

Année:

2012

Langue:

english

Fichier:

PDF, 363 KB

english, 2012

Managing MicroRNAs with Vector-Encoded Decoy-Type Inhibitors

Bak, Rasmus O, Hollensen, Anne Kruse, Mikkelsen, Jacob Giehm

Journal:

Molecular Therapy

Année:

2013

Langue:

english

Fichier:

PDF, 1.45 MB

english, 2013

miRNA sponges: soaking up miRNAs for regulation of gene expression

Bak, Rasmus O., Mikkelsen, Jacob Giehm

Journal:

Wiley Interdisciplinary Reviews: RNA

Année:

2014

Langue:

english

Fichier:

PDF, 547 KB

english, 2014

A lentiviral vector-based genetic sensor system for comparative analysis of permeability and activity of vitamin D3 analogues in xenotransplanted human skin

Staunstrup, Nicklas Heine, Bak, Rasmus O., Cai, Yujia, Svensson, Lars, Petersen, Thomas K., Rosada, Cecilia, Stenderup, Karin, Bolund, Lars, Mikkelsen, Jacob Giehm

Journal:

Experimental Dermatology

Année:

2013

Langue:

english

Fichier:

PDF, 578 KB

english, 2013

Cis -Acting Gene Regulatory Activities in the Terminal Regions of Sleeping Beauty DNA Transposon-Based Vectors

Moldt, Brian, Yant, Stephen R., Andersen, Peter Refsing, Kay, Mark A., Mikkelsen, Jacob Giehm

Journal:

Human Gene Therapy

Année:

2007

Langue:

english

Fichier:

PDF, 335 KB

english, 2007

Efficient Sleeping Beauty DNA Transposition From DNA Minicircles

Sharma, Nynne, Cai, Yujia, Bak, Rasmus O, Jakobsen, Martin R, Schrøder, Lisbeth Dahl, Mikkelsen, Jacob Giehm

Journal:

Molecular Therapy — Nucleic Acids

Année:

2013

Langue:

english

Fichier:

PDF, 951 KB

english, 2013

Driving DNA transposition by lentiviral protein transduction

Cai, Yujia, Mikkelsen, Jacob Giehm

Journal:

Mobile Genetic Elements

Année:

2014

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2014

Suppression of microRNAs by dual-targeting and clustered Tough Decoy inhibitors

Hollensen, Anne Kruse, Bak, Rasmus O., Haslund, Didde, Mikkelsen, Jacob Giehm

Journal:

RNA Biology

Année:

2013

Langue:

english

Fichier:

PDF, 2.72 MB

english, 2013

Genetic Reassortment and Patch Repair by Recombination in Retroviruses

Mikkelsen, Jacob Giehm, Pedersen, Finn Skou

Journal:

Journal of Biomedical Science

Année:

2000

Langue:

english

Fichier:

PDF, 1005 KB

english, 2000

Delivering the goods for genome engineering and editing

Skipper, Kristian Alsbjerg, Mikkelsen, Jacob Giehm

Journal:

Human Gene Therapy

Année:

2015

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2015

Robust lentiviral gene delivery but limited transduction capacity of commonly used AAV serotypes in xenotransplanted human skin

Jakobsen, Maria Vad, Askou, Anne Louise, Stenderup, Karin, Rosada, Cecilia, Dagnæs-Hansen, Frederik, Jensen, Thomas Gryesten, Corydon, Thomas Juhl, Mikkelsen, Jacob Giehm, Aagaard, Lars

Journal:

Human Gene Therapy Methods

Année:

2015

Langue:

english

Fichier:

PDF, 1.85 MB

english, 2015

Amelioration of Psoriasis by Anti-TNF-α RNAi in the Xenograft Transplantation Model

Jakobsen, Maria, Stenderup, Karin, Rosada, Cecilia, Moldt, Brian, Kamp, Søren, Dam, Tomas N, Jensen, Thomas G, Mikkelsen, Jacob Giehm

Journal:

Molecular Therapy

Année:

2009

Langue:

english

Fichier:

PDF, 664 KB

english, 2009

Hybrid Lentivirus-transposon Vectors With a Random Integration Profile in Human Cells

Staunstrup, Nicklas H, Moldt, Brian, Mátés, Lajos, Villesen, Palle, Jakobsen, Maria, Ivics, Zoltán, Izsvák, Zsuzsanna, Mikkelsen, Jacob Giehm

Journal:

Molecular Therapy

Année:

2009

Langue:

english

Fichier:

PDF, 227 KB

english, 2009

Mobilization of DNA transposable elements from lentiviral vectors

Bak, Rasmus O., Mikkelsen, Jacob Giehm

Journal:

Mobile Genetic Elements

Année:

2011

Langue:

english

Fichier:

PDF, 2.02 MB

english, 2011

Comparative Genomic Integration Profiling of Sleeping Beauty Transposons Mobilized With High Efficacy From Integrase-defective Lentiviral Vectors in Primary Human Cells

Moldt, Brian, Miskey, Csaba, Staunstrup, Nicklas Heine, Gogol-Döring, Andreas, Bak, Rasmus O, Sharma, Nynne, Mátés, Lajos, Izsvák, Zsuzsanna, Chen, Wei, Ivics, Zoltán, Mikkelsen, Jacob Giehm

Journal:

Molecular Therapy

Année:

2011

Langue:

english

Fichier:

PDF, 544 KB

english, 2011

Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus

Rasmussen, Tue Kruse, Andersen, Thomas, Bak, Rasmus Otkjær, Yiu, Gloria, Sørensen, Christian Møller, Stengaard-Pedersen, Kristian, Mikkelsen, Jacob Giehm, Utz, Paul Joseph, Holm, Christian Kanstrup, D

Journal:

Arthritis Research & Therapy

Année:

2015

Langue:

english

Fichier:

PDF, 1.73 MB

english, 2015

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

Thomsen, Martin K., Nandakumar, Ramya, Stadler, Daniela, Malo, Antje, Valls, Roser Marin, Wang, Fan, Reinert, Line S., Dagnaes-Hansen, Frederik, Hollensen, Anne Kruse, Mikkelsen, Jacob Giehm, Protzer,

Journal:

Hepatology

Année:

2016

Langue:

english

Fichier:

PDF, 1.83 MB

english, 2016

Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors

Askou, Anne Louise, Aagaard, Lars, Kostic, Corinne, Arsenijevic, Yvan, Hollensen, Anne Kruse, Bek, Toke, Jensen, Thomas Gryesten, Mikkelsen, Jacob Giehm, Corydon, Thomas Juhl

Journal:

Molecular Therapy — Methods & Clinical Development

Année:

2015

Langue:

english

Fichier:

PDF, 2.24 MB

english, 2015

574. Lentivirus Pre-Packed with Cas9 Protein for Safer Gene Editing

Swamy, Manjunath, Choi, Jang-Gi, Dang, Ying, Abraham, Sojan, Ma, Hongming, Guo, Hua, Cai, Yujia, Mikkelsen, Jacob Giehm, Wu, Haoquan, Shankar, Premlata

Journal:

Molecular Therapy

Année:

2016

Langue:

english

Fichier:

PDF, 298 KB

english, 2016

Improved microRNA suppression by WPRE-linked Tough Decoy microRNA sponges

Hollensen, Anne Kruse, Thomsen, Rune, Bak, Rasmus O, Petersen, Charlotte Christie, Ermegaard, Eva Reumert, Aagaard, Lars, Damgaard, Christian Kroun, Mikkelsen, Jacob Giehm

Journal:

RNA

Année:

2017

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2017

Suppression of choroidal neovascularization in mice by subretinal delivery of multigenic lentiviral vectors encoding anti-angiogenic microRNAs

Askou, Anne Louise, Benckendorff, Josephine Natalia Esther, Holmgaard, Andreas, Storm, Tina, Aagaard, Lars, Bek, Toke, Mikkelsen, Jacob Giehm, Corydon, Thomas Juhl

Journal:

Human Gene Therapy Methods

Année:

2017

Langue:

english

Fichier:

PDF, 3.50 MB

english, 2017

Suppression of Choroidal Neovascularization in Mice by Subretinal Delivery of Multigenic Lentiviral Vectors Encoding Anti-Angiogenic MicroRNAs

Askou, Anne Louise, Benckendorff, Josephine Natalia Esther, Holmgaard, Andreas, Storm, Tina, Aagaard, Lars, Bek, Toke, Mikkelsen, Jacob Giehm, Corydon, Thomas Juhl

Journal:

Human Gene Therapy Methods

Année:

2017

Langue:

english

Fichier:

PDF, 983 KB

english, 2017

Defective RNA sensing by RIG-I in severe influenza virus infection

Jørgensen, Sofie Eg, Christiansen, Mette, Ryø, Laura Barrett, Gad, Hans Henrik, Gjedsted, Jakob, Staeheli, Peter, Mikkelsen, Jacob Giehm, Storgaard, Merete, Hartmann, Rune, Mogensen, Trine Hyrup

Journal:

Clinical & Experimental Immunology

Année:

2018

Langue:

english

Fichier:

PDF, 2.71 MB

english, 2018

Time-Restricted PiggyBac DNA Transposition by Transposase Protein Delivery Using Lentivirus-Derived Nanoparticles

Skipper, Kristian Alsbjerg, Nielsen, Mathias Gaarde, Andersen, Sofie, Ryø, Laura Barrett, Bak, Rasmus O., Mikkelsen, Jacob Giehm

Journal:

Molecular Therapy — Nucleic Acids

Année:

2018

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2018

Viral delivery of genome-modifying proteins for cellular reprogramming

Mikkelsen, Jacob Giehm

Journal:

Current Opinion in Genetics & Development

Année:

2018

Langue:

english

Fichier:

PDF, 922 KB

english, 2018

Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein

Dalsgaard, Trine, Cecchi, Claudia R., Askou, Anne Louise, Bak, Rasmus O., Andersen, Pernille O., Hougaard, David, Jensen, Thomas G., Dagnæs-Hansen, Frederik, Mikkelsen, Jacob Giehm, Corydon, Thomas J.

Journal:

Molecular Therapy — Nucleic Acids

Année:

2018

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2018

Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs

Hollensen, Anne Kruse, Andersen, Sofie, Hjorth, Karina, Bak, Rasmus O., Hansen, Thomas B., Kjems, Jørgen, Aagaard, Lars, Damgaard, Christian Kroun, Mikkelsen, Jacob Giehm

Journal:

Molecular Therapy — Nucleic Acids

Année:

2018

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2018

Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy

Askou, Anne Louise, Alsing, Sidsel, Benckendorff, Josephine N.E., Holmgaard, Andreas, Mikkelsen, Jacob Giehm, Aagaard, Lars, Bek, Toke, Corydon, Thomas J.

Journal:

Molecular Therapy — Nucleic Acids

Année:

2019

Langue:

english

Fichier:

PDF, 2.52 MB

english, 2019

Targeted Knockout of the Vegfa Gene in the Retina by Subretinal Injection of RNP Complexes Containing Cas9 Protein and Modified sgRNAs

Holmgaard, Andreas Braae, Askou, Anne Louise, Jensen, Emilie Grarup, Alsing, Sidsel, Bak, Rasmus O., Mikkelsen, Jacob Giehm, Corydon, Thomas J.

Journal:

Molecular Therapy

Année:

2020

Fichier:

PDF, 4.80 MB

2020